Toyota Y, Kondo T, Shorin D, Sumii A, Kido K, Watanabe T, Otsuki S, Kanzaki R, Miyoshi H, Yasuda T, Horikawa YT, Mukaida K, Tsutsumi YM. Rapid dantrolene administration with body temperature monitoring is associated with decreased mortality in Japanese malignant hyperthermia events. BioMed Res Int 8340209, 2023.


Sumii A, Miyoshi H, Kato T, Otsuki S, Horikawa YT, Satomi S, Saeki N, Tsutsumi YM. Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report. Am J Case Rep 24: e939369, 2023.


Suga H,Miyoshi H, Arata K, Sumii A, Watanabe T, Kido K, Otsuki S Tsutsumi YM.Anesthetic management of cesarean section in COVID-19-positive pregnant women in Japan: Three case reports and review of the literature. Hiroshima J Med Sci 72: 21-25, 2023


Narasaki S, Noguchi S, Urabe T, Harada K, Hide I, Tanaka S, Yanase Y, Kajimoto T, Uchida K, Tsutsumi YM, Sakai N. Identification of protein kinase C domains involved in its translocation induced by propofol. Eur J Pharmacol 955: 175806, 2023.


Matsumoto A, Satomi S, Kakuta N, Narasaki S, Toyota Y, Miyoshi H, Horikawa YT, Saeki N, Tanaka K, and Tsutsumi YM. Remimazolam’s effects on postoperative nausea and vomiting are similar to those of propofol after laparoscopic gynecological surgery: a randomized controlled trial. J Clin Med 12: 5402, 2023.


三好寛二、堤保夫「悪性高熱症の診断と課題」『臨床麻酔』47: 21-27, 2023


森脇克行、平松咲子、新友里、木野下冨士子、河野浩和、堤保夫「手術室薬剤の投薬安全とセキュリティー:周術期管理チームのための基礎知識」『麻酔』72: 318-329, 2023.


森脇克行、中村隆治、堤保夫「新しいICD-11慢性疼痛コードの臨床応用」『産科と婦人科』59: 627-633, 2023.


科学研究費 基盤研究(C) 2023年度~2025年度 課題番号:23K08332





科学研究費 基盤研究(C) 2023年度~2027年度 課題番号:23K08409





科学研究費 基盤研究(C) 2023年度~2025年度 課題番号:23K08361





科学研究費 基盤研究(C) 2023年度~2025年度 課題番号:23K08382





科学研究費 若手研究 2023年度~2024年度 課題番号:23K15598







三好寛二、堤保夫 「6.12.1 眼球手術の麻酔」Page 509-513, 2022

佐伯昇 「7.5 筋疾患患者の麻酔」 Page 638-644, 2022



Urabe T, Miyoshi H, Narasaki S, Yanase Y, Uchida K, Noguchi S, Hide M, Tsutsumi YMand Sakai N. Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic. PLOS One 17: e0263395, 2022


Suzuki K, Shimizu Y, Ohshimo S, Oue K, Saeki N, Sadamori T, Tsutsumi Y, Irifune M, and Shime N. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system. Clin Exp Dent Res 8: 225-230, 2022.


Hiramatsu S, Moriwaki K, Nakao M, Tsutsumi YM. Rocuronium-induced respiratory paralysis refractory to sugammadex in Charcot-Marie-Tooth disease. Can J Anaesth 69: 364-368, 2022.


Hari Y, Satomi S, Murakami C, Narasaki S, Morio A, Kato T, Tsutsumi YM, Kakuta N, and Tanaka K. Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery. J Anesth 36: 265-269, 2022.


Narasaki S, Miyoshi H, Nakamura R, Sumii A, Watanabe T, Otsuki S, Tsutsumi YM. Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein. JA Clin Rep 8:29, 2022.


Ikeda T, Taguchi S, Sanuki M, Haraki T, Kato T, Tsutsumi YM. Awake craniotomy with intraoperative open magnetic resonance imaging under anesthesia management using an anesthesia information management system via a wireless local area network: Case report.  Interdisciplinary Neurosurgery 29: 101587, 2022


Otsuki S, Miyoshi H, Mukaida K, Yasuda T, Nakamura R, and Tsutsumi YM. Age-specific clinical features of pediatric malignant hyperthermia: a review of 187 cases over 60 years in Japan. Anesth Analg 135: 128-135, 2022.


Noda Y, Mukaida K, Miyoshi H, Nakamura R, Yasuda T, Saeki N, Nishino I, Tsutsumi YM. The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia. Anaesth Intens Care 50: 312-319, 2022.


Tsukamoto M, Kondo T, Miyoshi H, Toyota Y, Yokomi H, Sumii A, Shorin D, Takahashi S, and Tsutsumi YM. Postoperative tracheal compression requiring transposition of the brachiocephalic artery after Bentall surgery combined with total arch replacement in a patient with Loeys-Dietz syndrome. J Cardiothorac Vasc Anesth 36: 2532-2535, 2022.


Miyoshi H, Nakamura R, Otsuki S, Noda Y, Saeki N, and Tsutsumi YM. Electroencephalogram evaluation of accidental cerebral congestion during unexpected superior vena cava clamping: a case report. JA Clin Rep 8: 40, 2022.


Hachisuka R, Taguchi S, Moriwaki K, Oshita K, Umeda A, and Tsutsumi YM. Subacute postoperative myofascial pain diagnosed and treated successfully by ultrasound: a case after laparoscopic hepatectomy. JA Clin Rep 8: 53, 2022.


Kanzaki R, Morino H, Mukaida K, Kume K, Ohsawa R, Noda Y, Otsuki S, Miyoshi H, Kondo T, Nakamura R, Kawamoto M, Kawakami H, Tsutsumi Y. Genetic screening for malignant hyperthermia and comparison of clinical symptoms in Japan. Hiroshima J Med Sci 71: 31-38, 2022.


Watanabe T, Miyoshi H, Nakamura R, Otsuki S, Saeki N, Tsutsumi YM. Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report. JA Clin Rep 8: 80, 2022.


Miyoshi H, Watanabe T, Kido K, Kamiya S, Otsuki S, Narasaki S, Toyota Y, Kondo T, Horikawa YT, Saeki N, Tsutsumi YM. Remimazolam requires less vasopressor support during induction and maintenance of general anesthesia in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: A retrospective analysis from a single center. BioMed Res Int 6386606, 2022.


福井晴香、大下恭子、原木俊明、加藤貴大、神崎理英子、野田祐子、濱田宏、堤保夫「肥大型閉塞性心筋症合併患者の足関節固定術の麻酔経験―硬膜外麻酔と坐骨神経ブロックによる疼痛管理―」『麻酔』71:91-95, 2022


山口佳奈、大下恭子、中村隆治、濱田宏、堤保夫「硬膜外自己血パッチが著効を示した小児の硬膜穿刺後頭痛の1症例」『麻酔』71: 139-141, 2022.


科学研究費 基盤研究(C) 2022年度~2024年度 課題番号:22K09047





科学研究費 基盤研究(C) 2022年度~2024年度 課題番号:22K09037





科学研究費 基盤研究(C) 2022年度~2024年度 課題番号:22K09095





科学研究費 基盤研究(C) 2022年度~2024年度 課題番号:22K09070





科学研究費 若手研究 2022年度~2023年度 課題番号:22K16602





アジア・オーストラレーシア麻酔科学会 Travel Grant




Tsutsumi YM, Kakuta N, Kawanishi R, Tanaka K, Kanzaki R, Morio A, Noda Y, Miyoshi H, Kondo T, Mukaida K. Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report. J Anesth 35: 311-314, 2021.


Yasuda M, Moriawaki K, Tsutsumi YM. Concurrent positive skin tests to prophylactic antibiotics and rocuronium in two patients with life-threatening anaphylaxis after induction of anesthesia. JA Clin Rep 7: 37, 2021.


Morio A, Miyoshi H, Saeki N, Toyota Y, Tsutsumi YM. Acute-onset paraplegia as an unexpected complication under general anesthesia in supine position during abdominal endovascular aneurysm repair: a case report. JA Clin Rep 7: 44, 2021.


Miyoshi H, Nakamura R, Kido H, Narasaki S, Watanabe T, Yokota M, Ishii T, Kato T, Saeki N, Tsutsumi YM. Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study. Ann Palliat Med 10: 5119-5127, 2021.


Kamiya S, Nakamura R, Saeki N, Kondo T, Miyoshi H, Narasaki S, Morio A, Kawamoto M, Hirano H, Tsuji T, Tsutsumi YM. Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold. Sci Rep 11: 9558, 2021.


Miyoshi H, Kato T, Nakamura R, Saeki N, Noda Y, Kamiya S, Morio A, Tsutsumi YM. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats. J Anesth 35: 168-174, 2021.


Muneyasu T, Hirano H, Furui A, Soh Z, Nakamura R, Saeki N, Okada Y, Kawamoto M, Yoshizumi M, Yoshino A, Sasaoka T, Yamawaki S, Tsuji T. Cardiorespiratory synchronisation and systolic blood pressure correlation of peripheral arterial stiffness during endoscopic thoracic sympathectomy. Sci Rep 11: 5966, 2021.


Watanabe T, Miyoshi H, Noda Y, Narasaki S, Morio A, Toyota Y, Kimura H, Mukaida K, Yasuda T, Tsutsumi YM. Effects of remimazolam and propofol on Ca2+ regulation by ryanodine receptor 1 with malignant hyperthermia mutation. Biomed Res Int 8845129, 2021.


Tsuji T, Arikuni F, Sasaoka T, Suyama S, Akiyoshi T, Soh Z, Hirano H, Nakamura R, Saeki N, Kawamoto M, Yoshizumi M. Yoshino A, and Yamawaki S. Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study. Sci Rep 11: 4425, 2021.


Taguchi S, Saeki N, Morio A, Nakamura R, Kamiya S, Ikeda T, Oshita K, Hamada H, Miyata Y, Okada M, and Tsutsumi YM. Novel technique for identification of the pulmonary intersegmental plane using manual jet ventilation during pulmonary segmentectomy. Videosurgery Miniinv 16:169-174, 2021.


Inoue S, Miyoshi H, Hieda K, Hayashi T, Tsutsumi YM, Teishima J. Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy. Sci Rep 11: 5174, 2021.


Morio A, Tsutsumi R, Kondo T, Miyoshi H, Kato T, Narasaki S, Satomi S, Nakaya E, Kuroda M, Sakaue H, Kitamura T, Tsutsumi YM. Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling. Nutr Metab Cardiovasc Dis 31: 2979-2986, 2021.


Miyoshi H, Nakamura R, Noda Y, Kimura H, Watanabe T, Narasaki S, Kamiya S, Morio A, Toyota Y, Saeki N, Tsutsumi YM. Relationship between the loaded pressure and flow rate of packed red blood cells and various infusion solutions in normal infusion lines and catheters. Anesth Analg 133: 1107-1115, 2021.


Miyoshi M, Nakamura R, Noda Y, Yokomi H, Kamiya S, Morio A, Watanabe T, Narasaki S, Toyota Y, Saeki N, Hamada H, Tsutsumi YM. Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study. Ann Palliat Med 10: 10160-10169, 2021.


Morio A, Tsutsumi R, Satomi S, Kondo T, Miyoshi M, Kato T, Kuroda M, Kitamura T, Hara K, Saeki N, Sakaue H, and Tsutsumi YM. Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model. Diabetol Metab Syndr 13: 39, 2021


Taguchi S, Niinai H, Oshita K, Nakamura R, Hamada H, Tsutsumi YM. Femoral nerve paralysis induced by herpes zoster manifested after pain reduction: a case report. 『日本ペインクリニック学会誌』 28: 35-38, 2021.


Kamiya S, Nakamura R, Saeki N, Tsutsumi YM. Paradoxical increase in the photoplethysmography amplitude in response to nociceptive stimulation induced by tracheal intubation: A case report. J Med Invest 68: 383-385, 2021.


釈舎和子、加藤貴大、神谷諭史、堤保夫「喉頭浮腫により脳腫瘍摘出術後の抜管に難渋した1例」『ICUとCCU』45: 357-361, 2021


佐伯昇、中村隆治、神谷諭史、岡田芳幸、吉栖正生、辻敏夫、河本昌志、堤保夫「侵害刺激と血管:血管弾性研究で分かったこと」『麻酔・集中治療とテクノロジー』2021: 63-68, 2021


森脇克行、大下恭子、堤保夫「ICD-11時代のペインクリニック―国際疼痛学会 (IASP) 慢性疼痛分類に学ぶ」『日本ペインクリニック学会誌』28: 91-99, 2021


片岡宏子、大下恭子、田口志麻、加藤貴大、濱田宏、堤保夫「肩関節手術後の持続斜角筋間ブロック中に肺塞栓を併発した1例」『日本臨床麻酔学会誌』41: 322-326, 2021


梶川洋子、田口志麻、加藤貴大、大下恭子、濱田宏、堤保夫「胆道閉鎖症手術後に超音波ガイド下傍脊椎ブロックを施行し術後早期の鎮痛を試みた新生児の1例」『日本臨床麻酔学会誌』41: 47-53, 2021


神谷諭史、釋舎和子、野田祐子、森尾篤、三好寛二、近藤隆志、中村隆治、堤保夫「ICU入室が腹部ステントグラフト内挿入術後患者の術後せん妄発症に与える影響」『Cardiovascular Anesthesia』25:13-19, 2021


釈舎和子、加藤貴大、神谷諭史、堤保夫「喉頭浮腫により脳腫瘍摘出術後の抜管に難渋した1例」『ICUとCCU』45: 357-361, 2021


池田豪、三好寛二、森尾篤、楢崎壮志、野田祐子、神谷諭史、近藤隆志、加藤貴大、堤保夫「腹部ステントグラフト内挿入後のType2エンドリークに対する開腹下の流入血管結紮・瘤縫縮術の麻酔経験」『Cardiovascular Anesthesia』25:89-93, 2021


科学研究費 基盤研究(C) 2021年度~2023年度 課題番号:21K08923





科学研究費 基盤研究(C) 2021年度~2023年度 課題番号:21K08996





科学研究費 基盤研究(C) 2021年度~2023年度 課題番号:21K08948





科学研究費 若手研究 2021年度~2022年度 課題番号:21K16560

研究課題名: プロポフォールの多角的作用機序の解析 ープロポフォール誘発副作用の解決に向けてー




科学研究費 研究活動スタート支援 2021年度~2022年度 課題番号:21K20952











事 業 概 要:飛沫防止カバーの製品化




2021.3.23 博士(医学) 甲第8519号 卜部智晶 

学位論文:Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria. Eur J Pharm 884; 173303, 2020.


2021.5.27 博士(医学) 乙第4429号 田口志麻

学位論文:Novel technique for identification of the pulmonary intersegmental plane using manual jet ventilation during pulmonary segmentectomy. Videosurgery Miniinv 16:169-174, 2021.


2021.8.26 博士(医学) 甲第8626号 神谷諭史

学位論文:Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold. Sci Rep 11: 9558, 2021.



『新臨床麻酔スタンダード 総論』克誠堂出版

佐伯 昇 「18. 麻酔と体位」 page 363-376, 2020



Kondo T, Toyota Y, Narasaki S, Watanabe T, Miyoshi H, Saeki N, Tsutsumi YM. Intraoperative responses of motor evoked potentials to the novel intravenous anesthetic remimazolam during spine surgery: a report of two cases.  JA Clin Rep 6: 97, 2020


Tsuji T, Nobukawa T, Mito A, Hirano H, Soh Z, Inokuchi R, Fujita E, Ogura Y, Kaneko S, Nakamura R, Saeki N, Kawamoto M, Yoshizumi M.  Recurrent probabilistic neural network-based short-term prediction for acute hypotension and ventricular fibrillation.  Sci Rep 10: 11970, 2020


Kondo H, Nakamura R, Kobatake A, Nao Y, Hashimoto K, Nakatani K. Effects of intravenous injection of indocyanine green on the oxygen reserve index (ORi). J Anesth 34: 338-341, 2020


Moriwaki M, Watanabe T, Yasuda M, Katagiri T, Ueki M, Kurita S, Sanuki M, Tsutsumi YM.  An outcome study of adult in-hospital cardiac arrests in non-monitored areas with resuscitation attempted using AED.  Am J Emerg Med 38: 2524-2530, 2020


Murakami C, Kakuta N, Satomi S, Nakamura R, Miyoshi H, Morio A, Saeki N, Kato T, Ohshita N, Tanaka K, Tsutsumi YM. Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis. Braz J Anestesiol 70:508-519, 2020


Kondo T, Saeki N, Otsuki S, Tsutsumi YM. Evaluation of a new face mask concept for oxygen administration: a crossover study in healthy volunteers. J Anesth 34: 950-952, 2020


Urabe T, Yanase Y, Motoike S, Harada K, Hide I, Tanaka S, Tsutsumi YM, Kawamoto M, Sakai N. Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria. Eur J Pharm 884; 173303, 2020


Kondo T, Izumi H, Kitagawa M.  Comparison of the effects of desflurane, sevoflurane, and propofol on the glottic opening area during remifentanil-based general anesthesia using a supraglottic airway device.  Anesthesiol Res Pract 2020: 1302898, 2020


Satomi S, Morio A, Miyoshi H, Nakamura R, Tsutsumi R, Sakaue H, Yasuda T, Saeki N, Tsutsumi YM.  Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury. Life Sci 245: 117368, 2020


Sebe M, Tsutsumi R, Oyama T, Horikawa YT, Uemura Y, Kakuta N, Sakai Y, Morio A, Miyoshi H, Kondo T, Urabe T, Noda Y, Kamiya S, Saeki N, Kuroda M, Tanaka K, Tsutsumi YM, Sakaue H.   Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatherter aortic valve implantation in elderly patients.  J Med Invest 67: 139-144, 2020


釋舎和子、近藤隆志、堤保夫「肺動脈弁狭窄症を合併した先天性肝外門脈体循環シャントに対する開腹シャント血管結紮術の術中管理」『日本小児麻酔学会誌』26:54-57, 2020


三好寛二、安田季道、堤保夫「悪性高熱症素因疑い」『周術期管理 LiSA別冊秋号』27: 253-260, 2020


池尻祐美、大下恭子、中村隆治、濱田宏、林優美、倉田明子、岡本泰昌、河本昌志、堤保夫 「がん性神経障害性疼痛における神経障害性疼痛スクリーニング質問票の妥当性の検討」Palliat Care Res 15:15-20, 2020


科学研究費 若手研究 
2020年度~2021年度 課題番号:20K17783





科学研究費 若手研究 2020年度~2021年度 課題番号:20K17812





科学研究費 若手研究 2020年度~2021年度 課題番号:20K17813





上原記念生命科学財団 研究推進特別奨励金








濱田宏 「7.悪性高熱ガイドライン」page 37-42, 2019

讃岐美智義 「20.麻酔深度とモニター活用法」page 108-117, 2019



Miyoshi H, Hamada H, Nakamura R, Kondo T, Yasuda, Saeki N, Kawamoto M.  Postoperative thoracic and low back pain following endovascular aortic repair associated with stenting location.  J Anesth 33: 75-9, 2019


Tanaka H, Mito A, Hirano H, Soh Z, Nakamura R, Saeki N, Kawamoto M, Higashi Y, Yoshizumi M, Tsuji T. Estimation of arterial viscosity based on an oscillometric method and its application in evaluating the vascular endothelial function. Sci Rep 22: 2609, 2019


Hagiyama N, Hirano H, Mito A, Soh Z, Fujita E, Ogura Y, Kaneko S, Nakamura R, Saeki N, Kawamoto M, Yoshizumi M, Tsuji T. Unconstrained vital sign monitoring system using an aortic pulse wave sensor. Sci Rep 9: 17475, 2019


Asano M, Motoike S, Yokota C, Usuki N, Yamamoto H, Urabe T, Katarao K, Hide I, Tanaka S, Kawamoto M, Irifune M, Sakai N. SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism. J Pharmacol Sci 139: 29-36, 2019


Fukuhara K, Kondo T, Miyoshi H, Hamada H, Kawamoto M.  Rotational thromboelastometry-guided perioperative management of coagulation in a patient with Heyde’s syndrome undergoing transcatheter aortic valve implantation.  JA Clin Rep 5: 3, 2019


呉晟名、高橋信也、森田翔平、前田和樹、片山桂次郎、黒崎達也、近藤隆志、村下純二、末田泰二郎「大動脈基部・上行置換術後の覚醒遅延に門脈体循環シャントの関与が疑われた一例」『Cardiovascular Anesthesia』23: 83-87, 2019


卜部智晶、加藤貴大、田口志麻、古屋美香、濱田宏、河本昌志 「小児気道異物9症例の検討」 『麻酔』68: 363-368, 2019


讃岐美智義 「近未来の全身麻酔方法 開発されるべきモニター」 『麻酔』68: 868-874, 2019


讃岐美智義 「AIMSの守備範囲とグレード(讃岐分類) 松・竹・梅の提案」 『LiSA』26: 150-152, 2019


三好寛二、中村隆治、近藤隆志、堤保夫「血管内ステントと痛み」『臨床麻酔』43: 1484-1488, 2019


仁井内浩、佐藤一史、家俊博、高松千洋「立会い等にかかわる医療機器業者の質に関するアンケート調査」『日本手術医学会雑誌』 40: 158-160, 2019


科学研究費 基盤(
C) 2019年度~2021年度 課題番号:19K09353





科学研究費 若手研究 2019年度~2022年度 課題番号:19K18275





科学研究費 若手研究 2019年度~2021年度 課題番号:19K18298





日本麻酔科学会第66回学術集会 最優秀演題(麻酔科関連-2Q-OP1-2